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Role of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature.

Authors :
Orhurhu, Vwaire
Schwartz, Ruben
Potts, Jacob
Peck, Jacqueline
Urits, Ivan
Orhurhu, Mariam Salisu
Odonkor, Charles
Viswanath, Omar
Kaye, Alan
Gill, Jatinder
Kaye, Alan D
Source :
Current Pain & Headache Reports; Nov2019, Vol. 23 Issue 11, p1-9, 9p
Publication Year :
2019

Abstract

<bold>Purpose Of Review: </bold>Chronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PRP).<bold>Recent Findings: </bold>Alpha-2-microglobulin, a 720-kD protein complex, is an active protease inhibitor with tremendous anti-inflammatory properties in animal models. A growing body of evidence suggests that this complex is the most instrumental factor for cartilage preservation in PRP injections. As an active component of platelet-rich plasma's anti-inflammatory properties, alpha-2-microglobulin has been shown to be an active inhibitor of joint degeneration, cartilage preservation, and improvement in quality of life for patients with knee osteoarthritis compared with a multitude of other modalities. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15313433
Volume :
23
Issue :
11
Database :
Complementary Index
Journal :
Current Pain & Headache Reports
Publication Type :
Academic Journal
Accession number :
139095506
Full Text :
https://doi.org/10.1007/s11916-019-0822-9