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Role of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature.
- Source :
- Current Pain & Headache Reports; Nov2019, Vol. 23 Issue 11, p1-9, 9p
- Publication Year :
- 2019
-
Abstract
- <bold>Purpose Of Review: </bold>Chronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PRP).<bold>Recent Findings: </bold>Alpha-2-microglobulin, a 720-kD protein complex, is an active protease inhibitor with tremendous anti-inflammatory properties in animal models. A growing body of evidence suggests that this complex is the most instrumental factor for cartilage preservation in PRP injections. As an active component of platelet-rich plasma's anti-inflammatory properties, alpha-2-microglobulin has been shown to be an active inhibitor of joint degeneration, cartilage preservation, and improvement in quality of life for patients with knee osteoarthritis compared with a multitude of other modalities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15313433
- Volume :
- 23
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Current Pain & Headache Reports
- Publication Type :
- Academic Journal
- Accession number :
- 139095506
- Full Text :
- https://doi.org/10.1007/s11916-019-0822-9