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Association between early prenatal exposure to ambient air pollution and birth defects: evidence from newborns in Xi'an, China.
- Source :
- Journal of Public Health; Sep2019, Vol. 41 Issue 3, p494-501, 8p
- Publication Year :
- 2019
-
Abstract
- Background The aim of this study was to investigate an association between birth defects and exposure to sulfur dioxide (SO<subscript>2</subscript>), nitrogen dioxide (NO<subscript>2</subscript>) and particles ≤10 μm in an aerodynamic diameter (PM<subscript>10</subscript>) during early pregnancy in Xi'an, China. Methods Birth defect data were from the Birth Defects Monitoring System of Xi'an, and data on ambient air pollutants during 2010–15 were from the Xi'an Environmental Protection Bureau. A generalized additive model (GAM) was used to investigate the relationship between birth defects and ambient air pollutants. Results Among the 8865 cases with birth defects analyzed, the overall incidence of birth defects was 117.33 per 10 000 infants. Ambient air pollutant exposure during the first trimester increased the risk of birth defects by 10.3% per 10 μg/m<superscript>3</superscript> increment of NO<subscript>2</subscript> and 3.4% per 10 μg/m<superscript>3</superscript> increment of PM<subscript>10</subscript>. No significant association was found between birth defects and SO<subscript>2</subscript>. Moreover, NO<subscript>2</subscript> increased risk of neural tube defects, congenital heart disease, congenital polydactyly, cleft palate, digestive system abnormalities and gastroschisis, and PM<subscript>10</subscript> was associated with congenital heart disease and cleft lip with or without cleft palate. Conclusions Chinese women should avoid exposure to high levels of NO<subscript>2</subscript> and PM<subscript>10</subscript> during the first 3 months of pregnancy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17413842
- Volume :
- 41
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Public Health
- Publication Type :
- Academic Journal
- Accession number :
- 139059056
- Full Text :
- https://doi.org/10.1093/pubmed/fdy137