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Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS.
- Source :
- International Journal of Endocrinology; 10/3/2019, p1-8, 8p
- Publication Year :
- 2019
-
Abstract
- Background. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs. However, little information is available about sequelae following DIHS/DRESS resolution from an endocrinologist's perspective. This study aimed to investigate the endocrine sequelae following DIHS/DRESS, from clinical feature to etiology. Methods. We retrospectively analyzed the patients diagnosed with DIHS/DRESS in Peking Union Medical College Hospital (PUMCH) during the period of 1 January 2012 to 31 December 2017, and those who developed endocrine disorders after DIHS/DRESS were further examined. We also reviewed the literature, from 1 January 2000 to 31 December 2017, on involvement of endocrine glands in DIHS/DRESS patients. Results. Three patients developed both autoimmune thyroid disease (AITD) and type 1 diabetes (T1DM)/fulminant type 1 diabetes (FT1DM) of the 45 patients. Seven cases involving more than two endocrine glands were reported in the literature. Our results indicated that DIHS/DRESS is a potential etiological factor of autoimmune polyendocrine syndrome (APS), especially APS III. Conclusions. Patients require careful long-term follow-up after DIHS/DRESS. Involvement of endocrine glands, especially FT1DM, should always be monitored in patients with a history of DIHS/DRESS. This study indicated that DIHS/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 1 diabetes
ENDOCRINE glands
DRUG side effects
THYROID diseases
CLOTHING & dress
Subjects
Details
- Language :
- English
- ISSN :
- 16878337
- Database :
- Complementary Index
- Journal :
- International Journal of Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 138933749
- Full Text :
- https://doi.org/10.1155/2019/7959615