Convolution kernel and iterative reconstruction affect the diagnostic performance of radiomics and deep learning in lung adenocarcinoma pathological subtypes.

Background: The aim of this study was to investigate the influence of convolution kernel and iterative reconstruction on the diagnostic performance of radiomics and deep learning (DL) in lung adenocarcinomas. Methods: A total of 183 patients with 215 lung adenocarcinomas were included in this study. All CT imaging data was reconstructed with three reconstruction algorithms (ASiR at 0%, 30%, 60% strength), each with two convolution kernels (bone and standard). A total of 171 nodules were selected as the training‐validation set, whereas 44 nodules were selected as the testing set. Logistic regression and a DL framework‐DenseNets were selected to tackle the task. Three logical experiments were implemented to fully explore the influence of the studied parameters on the diagnostic performance. The receiver operating characteristic curve (ROC) was used to evaluate the performance of constructed models. Results: In Experiments A and B, no statistically significant results were found in the radiomic method, whereas two and six pairs were statistically significant (P < 0.05) in the DL method. In Experiment_C, significant differences in one and four models were found in the radiomics and DL methods, respectively. Moreover, models constructed with standard convolution kernel data outperformed that constructed with bone convolution kernel data in all studied ASiR levels in the DL method. In the DL method, B0 and S60 performed best in bone and standard convolution kernel, respectively. Conclusion: The results demonstrated that DL was more susceptible to CT parameter variability than radiomics. Standard convolution kernel images seem to be more appropriate for imaging analysis. Further investigation with a larger sample size is needed. [ABSTRACT FROM AUTHOR]