THE EFFECT OF NANOPARTICLES ON MINERAL METABOLISM IN THE BODY OF LABORATORY ANIMALS.

The aim of this study was to investigate the effect of additional dietary chromium in various forms on the exchange of elements in rats. Ultradisperse chromium particles at a dose of 300 µg/kg of feed contributed to significant changes relative to the control, including a 2.38 fold increase in calcium, a 15.00 fold increase in phosphorus and a 3.60 fold decrease in chromium. Relative to the control group, the introduction of 300 µg/kg chromium chloride into the diet led to an 9.04 fold increase in P, 7.77 times more B and 2.00 times less Cr, and 1.57 times less iron, relative to the control. Inclusion of chromium picolinate in the diet of experimental animals at a dose of 300 µg/kg of feed led to a significant increase in both macro- and microelements. Among the essential elements, there was 3.00 times more B, 4.2 time more cobalt, 5.55 times more lithium, a 40.2% increase in manganese, 11.1 times more nickel, 2.24 times more silicon and a 44.5% increase in zinc. An increase in the dosage of chromium nanoparticles, chromium chloride and chromium picolinate to 500 µg/kg led to a significant increase in macronutrients, such as P in experimental groups 4, 5 and 6, which increased by 12.8 fold (p ≤ 0.01), 95.9% (p ≤ 0.001) and 14.7 fold (p ≤ 0.01), respectively, relative to the control group. Thus, the introduction of chromium has a multidirectional effect, which should be taken into account when assessing the mineral security of the diet. [ABSTRACT FROM AUTHOR]