ECTRIMS 2019 – Oral Presentations.

Over recent years there have been significant advances in our understanding of the pathogenesis of Paediatric Multiple Sclerosis (MS) together with a growing recognition of the diverse range of disorders which can present as non-MS white matter lesions on brain and spine MRI in children and young people. B Objectives: b To assess the association between sNfL and MS demographic and disease characteristics as well as the impact of comorbidities on sNfL levels in a large heterogeneous cohort of MS patients. MS patients with sNfL-E vs. sNfL-N were compared with respect to walking speed, manual dexterity, and processing speed using linear models (GLMs) adjusting for age, sex, disease subtype/duration and MS therapy. B Results: b Of the 1969 MS patients (74% female; mean age 48y [SD: 12.0y]; 18% non-white), 483 (25%) participants were classified as sNfL-E. Relative to sNfL-N, MS patients with sNfL-E had slower walking and manual dexterity speeds (mean %difference [95% CI]: walking speed: 10% slower [6%, 14%]; p< 0.001; manual dexterity: 7% slower [5%, 10%]; p< 0.001) and lower processing speed scores (mean difference -3.78 [-4.84, -2.70]; p< 0.001). [Extracted from the article]