Ultrasonic Investigations on Molecular Interactions of N-Phthaloyl Сompounds in Рrotic and Non-Protic Solvents at 303–318 K.

Ultrasonic studies of (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanoic acid (NPTLU), 2-(2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-2-oxoethyl)isoindoline-1,3-dione (C‑BI-CL-L), 2-(4-methyl-1-(2-(4-nitrophenyl)-1H-benzo [d]imidazol-1-yl) -1-oxopentan-2-yl)isoindoline-1,3-dione (C-BI-NO₂-L), 2-(1-(2-(4-nitrophenyl)-1H-benzo[d]imidazol-1-yl)-1-oxobutan-2-yl)-2,3-dihydroinden-1-one (C-BI-NO₂-G), 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl) acetamide (C-QA-GL), and 1-(2-((4-oxo-2-phenylquinqxolin-3(4H)-yl)carbamoyl)benzoyl)pyrrolidine-2-carboxylic acid (C-QA-PR) in solution of polar and non-polar solvent of various concentrations at 303–318 K. Density and ultrasonic velocity measured and with the help of these data, different thermo-acoustical parameters viz. adiabatic compressibility, intermolecular free length, acoustic impedance, surface tension, Rao's constant, molar volume, Wada's constant calculated using standard formulas. The variation of these parameters with concentration and temperature studied using graphical representations of these parameters. Ethyl alcohol and DMSO were chosen as polar and non-polar solvents, respectively. The variation in different properties reveals the presence of specific molecular interactions in solute and solvent used, which will give information regarding drug transmission and absorption. [ABSTRACT FROM AUTHOR]