MEIS transcription factors in development and disease.

MEIStranscription factors are key regulators ofembryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprisingmechanisms bywhich these proteins control gene expression. This Primer summarizes recent findings aboutMEIS protein activity and regulation in development, and discusses new insights into the role ofMEIS genes in disease, focusing on the pathogenesis of solid cancers. [ABSTRACT FROM AUTHOR]