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The different expression of caspase-1 in HBV-related liver disease and acts as a biomarker for acute-on-chronic liver failure.
- Source :
- BMC Gastroenterology; 8/20/2019, Vol. 19 Issue 1, pN.PAG-N.PAG, 1p, 1 Color Photograph, 2 Charts, 4 Graphs
- Publication Year :
- 2019
-
Abstract
- <bold>Background: </bold>Caspase-1 is an evolutionarily conserved enzyme that proteolytically cleaves the precursors of the inflammatory cytokines interleukin 1β and interleukin 18. However, the role of caspase-1 in determining the severity of acute-on-chronic liver failure (ACLF) has yet to be elucidated. We evaluated the expression levels of caspase-1 in HBV-related liver disease and assessed its utility as a biomarker predicting the severity of ACLF.<bold>Methods: </bold>The gene, protein and activity levels of caspase-1 were measured in the liver and/or serum of subjects with HBV-related disease. We also analysed the correlation between the expression levels of caspase-1 and liver injury of ACLF.<bold>Results: </bold>Compared with the values observed in normal subjects, the relative caspase-1 mRNA and protein levels in livers were decreased in patients with CHB, LC, and HCC but increased in those with ACLF; moreover, ACLF patients had the lowest serum level and hepatic activity of caspase-1 among the five groups. The serum caspase-1 levels in ACLF patients showed a negative correlation with total serum bilirubin and a positive correlation with serum total protein and albumin. Importantly, the serum caspase-1 levels in the surviving group with ACLF were higher than those in the non-surviving group and showed different dynamic trends. Analyses of the area under the receiver operating characteristic curve indicated that caspase-1 (AUC = 0.84, AUC of MELD score = 0.72) may be a useful marker for independently predicting ACLF.<bold>Conclusion: </bold>Caspase-1 is a potential non-invasive biomarker of disease progression and prognosis in ACLF. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1471230X
- Volume :
- 19
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 138157558
- Full Text :
- https://doi.org/10.1186/s12876-019-1064-3