Back to Search Start Over

New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.

New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.

Authors :
Hoogerwerf, Marie-Astrid
Coffeng, Luc E
Brienen, Eric A T
Janse, Jacqueline J
Langenberg, Marijke C C
Kruize, Yvonne C M
Gootjes, Chelsea
Manurung, Mikhael D
Dekker, Mark
Becker, Luke
Erkens, Marianne A A
Beek, Martha T van der
Ganesh, Munisha S
Feijt, Carola
Winkel, Beatrice M F
Westra, Inge M
Meij, Pauline
Loukas, Alex
Visser, Leo G
Vlas, Sake J de
Source :
Journal of Infectious Diseases; 9/15/2019, Vol. 220 Issue 6, p1044-1048, 5p
Publication Year :
2019

Abstract

Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00221899
Volume :
220
Issue :
6
Database :
Complementary Index
Journal :
Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
138057624
Full Text :
https://doi.org/10.1093/infdis/jiz218