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New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections.
- Source :
- Journal of Infectious Diseases; 9/15/2019, Vol. 220 Issue 6, p1044-1048, 5p
- Publication Year :
- 2019
-
Abstract
- Four healthy volunteers were infected with 50 Necator americanus infective larvae (L3) in a controlled human hookworm infection trial and followed for 52 weeks. The kinetics of fecal egg counts in volunteers was assessed with Bayesian multilevel analysis, which revealed an increase between weeks 7 and 13, followed by an egg density plateau of about 1000 eggs/g of feces. Variation in egg counts was minimal between same-day measurements but varied considerably between days, particularly during the plateau phase. These analyses pave the way for the controlled human hookworm model to accelerate drug and vaccine efficacy studies. [ABSTRACT FROM AUTHOR]
- Subjects :
- HOOKWORMS
EXCRETION
VACCINE effectiveness
EGGS
NEMATODE physiology
ANIMAL experimentation
BIOLOGICAL models
BLOOD cell count
COMPARATIVE studies
EOSINOPHILS
FECES
HOOKWORM disease
INSECT larvae
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
NEMATODES
PROBABILITY theory
RESEARCH
EVALUATION research
HUMAN research subjects
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 220
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 138057624
- Full Text :
- https://doi.org/10.1093/infdis/jiz218