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New Benzaldehyde and Benzopyran Compounds from the Endophytic Fungus Paraphaeosphaeria sp. F03 and Their Antimicrobial and Cytotoxic Activities *.
- Source :
- Planta Medica; 2019, Vol. 85 Issue 11/12, p957-964, 8p
- Publication Year :
- 2019
-
Abstract
- Three new benzaldehyde derivatives, sporulosaldeins A – C (1 – 3), and 3 new benzopyran derivatives, sporulosaldeins D – F (4 – 6), were discovered from an endophytic fungus, Paraphaeosphaeria sp. F03, which was isolated from Paepalanthus planifolius leaves. Compounds 1 – 6 were elucidated by 1- and 2-dimensional nuclear magnetic resonance experiments and high-resolution mass spectrometry analysis. The absolute configuration of compound 5 was determined through the comparison of experimental and calculated electronic circular dichroism data. Compounds 1 – 6 were found to exhibit antifungal activity with minimum inhibitory concentration (MIC) values of 7.8 – 250 µg/mL and racemic mixture of compound 6 exhibited weak cytotoxicity against MCF-7 and LM3 with IC<subscript>50</subscript> values of 34.4 and 39.2 µM, respectively. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00320943
- Volume :
- 85
- Issue :
- 11/12
- Database :
- Complementary Index
- Journal :
- Planta Medica
- Publication Type :
- Periodical
- Accession number :
- 137950186
- Full Text :
- https://doi.org/10.1055/a-0853-7793