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An alternative stereoselective total synthesis of (-)-pyrenophorol.
- Source :
- Natural Product Research; Oct2019, Vol. 33 Issue 19, p2738-2743, 6p
- Publication Year :
- 2019
-
Abstract
- The total synthesis of 16-membered C<subscript>2</subscript>–Symmetric dilactone (-)-Pyrenophorol was accomplished starting from commercially available (S)-epoxide prepared by hydrolytic kinetic resolution of (±) – epoxide with key steps of Grignard reaction, Swern oxidation, Wittig reaction and cyclization was achieved by intermolecular Mitsunobu cyclization. The synthesis of (-)-Pyrenophorol accomplished from cheaply available starting material, easily work-up procedures and reduction of cost in industrial process were major advantages of this route. [ABSTRACT FROM AUTHOR]
- Subjects :
- WITTIG reaction
COST control
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 33
- Issue :
- 19
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 137924528
- Full Text :
- https://doi.org/10.1080/14786419.2018.1499636