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Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012.
- Source :
- Infection & Drug Resistance; Jul2019, Vol. 12, p2251-2257, 7p
- Publication Year :
- 2019
-
Abstract
- Background: Latent tuberculosis infection (LTBI) is a precursor of active tuberculosis diseases and an important issue in the United States and worldwide. The association between vitamin D deficiency and LTBI is poorly understood. Methods: From 2011 to 2012, the National Health and Nutrition Examination Survey (NHANES) assessed LTBI (according to tuberculin skin testing and QuantiFERON<superscript>®,</superscript>-TB Gold In-Tube) and measured serum levels of vitamin D. We evaluated the association between LTBI and vitamin D using multivariate logistic regression models adjusted for known confounders. Results: The LTBI group had a lower 25-hydroxyvitamin D [25(OH)D] level than the non-LTBI group (p=0.0012). The adjusted risk of LTBI was significantly higher among participants with serum 25(OH)D levels <12 ng/ml (adjusted OR [aOR], 2.27; 95% CI, 1.40–3.66) and 12–19 ng/ml (aOR, 1.75; 95% CI, 1.25–2.46) compared to those with a level ≥30 ng/ml. The higher risk of LTBI among the participants with serum 25(OH)D levels <12 ng/ml and 12–19 ng/ml remained unchanged in both male and summer season subgroups. Conclusions: A low serum 25(OH)D level was significantly associated with the risk of LTBI in this US cohort. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11786973
- Volume :
- 12
- Database :
- Complementary Index
- Journal :
- Infection & Drug Resistance
- Publication Type :
- Academic Journal
- Accession number :
- 137914307
- Full Text :
- https://doi.org/10.2147/IDR.S213845