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Transmission of Porcine Circovirus 3 (PCV3) by Xenotransplantation of Pig Hearts into Baboons.
- Source :
- Viruses (1999-4915); Jul2019, Vol. 11 Issue 7, p650-650, 1p
- Publication Year :
- 2019
-
Abstract
- Porcine circovirus 3 (PCV3) is a newly described member of the virus family Circoviridae. PCV3 is highly distributed among pigs and wild boars worldwide. A sudden introduction of PCV3 was recently observed in a herd of triple genetically modified pigs generated for xenotransplantation. These animals were used as donor pigs for orthotopic heart transplantation into baboons. In four cases, PCV3-positive hearts were transplanted, and transmission of PCV3 to the recipient was observed. PCV3 was found in all organs of the recipient baboons and a higher virus load was found in animals with a longer survival time of the transplant, indicating replication of the virus. This is the first report showing trans-species transmission of PCV3 to baboons by transplantation of a heart from a PCV3-positive donor pig. Sequence analysis showed that PCV3a and PCV3b were present in the infected pigs and were transmitted. Experiments to infect human 293 cells with PCV3 failed. [ABSTRACT FROM AUTHOR]
- Subjects :
- XENOTRANSPLANTATION
BABOONS
SWINE
HEART transplantation
WILD boar
VIRAL replication
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 11
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Viruses (1999-4915)
- Publication Type :
- Academic Journal
- Accession number :
- 137830093
- Full Text :
- https://doi.org/10.3390/v11070650