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Prognostic Role of Androgen Receptor in Triple Negative Breast Cancer: A Multi-Institutional Study.
- Source :
- Cancers; Jul2019, Vol. 11 Issue 7, p995-995, 1p
- Publication Year :
- 2019
-
Abstract
- Background: The androgen receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR's prognostic role in TNBC are putting its usefulness in question. Some studies conclude that AR positivity indicates a good prognosis in TNBC, whereas others suggest the opposite, and some show that AR status has no significant bearing on the patients' prognosis. Methods: We evaluated the prognostic value of AR in resected primary tumors from TNBC patients from six international cohorts {US (n = 420), UK (n = 239), Norway (n = 104), Ireland (n = 222), Nigeria (n = 180), and India (n = 242); total n = 1407}. All TNBC samples were stained with the same anti-AR antibody using the same immunohistochemistry protocol, and samples with ≥1% of AR-positive nuclei were deemed AR-positive TNBCs. Results: AR status shows population-specific patterns of association with patients' overall survival after controlling for age, grade, population, and chemotherapy. We found AR-positive status to be a marker of good prognosis in US and Nigerian cohorts, a marker of poor prognosis in Norway, Ireland and Indian cohorts, and neutral in UK cohort. Conclusion: AR status, on its own, is not a reliable prognostic marker. More research to investigate molecular subtype composition among the different cohorts is warranted. [ABSTRACT FROM AUTHOR]
- Subjects :
- BREAST cancer prognosis
BREAST tumor diagnosis
IMMUNOGLOBULIN analysis
AGE distribution
BREAST tumors
CANCER chemotherapy
IMMUNOHISTOCHEMISTRY
LONGITUDINAL method
MEDICAL cooperation
MEDICAL protocols
RESEARCH
STAINS & staining (Microscopy)
SURVIVAL
TUMOR markers
TUMOR classification
TREATMENT effectiveness
ANDROGEN receptors
TUMOR grading
BLOOD
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 11
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 137798523
- Full Text :
- https://doi.org/10.3390/cancers11070995