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Protein inhibitor of activated STAT genes are differentially expressed in breast tumor tissues.
- Source :
- Personalized Medicine (17410541); Jul2019, Vol. 16 Issue 4, p277-285, 9p
- Publication Year :
- 2019
-
Abstract
- Aim: Protein inhibitor of activated STAT (PIAS) family includes transcriptional regulator proteins with SUMO E3 ligase activity. They regulate expression of several genes involved in cell proliferation, differentiation and survival. Method: We evaluated expression of PIAS1–4 genes in 54 breast cancer tissues and their paired adjacent noncancerous tissues. Results:PIAS2 and PIAS3 genes were significantly downregulated in tumoral tissues compared with adjacent noncancerous tissues. PIAS1–3 expressions were significantly lower in estrogen receptor (ER+) samples compared with ER- samples while PIAS4 had the opposite trend. PIAS3 expression was significantly higher in grade 1 samples compared with grade 2 samples. Conclusion: These findings highlight the role of PIAS genes in the pathogenesis of breast cancer and their association with determinants of response to antihormone therapies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17410541
- Volume :
- 16
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Personalized Medicine (17410541)
- Publication Type :
- Academic Journal
- Accession number :
- 137778869
- Full Text :
- https://doi.org/10.2217/pme-2018-0070