Development of Analytical Method to Monitor Dissolution of Bepotastine Besilate Tablet.

Bepotastine Besilate is an anti-histaminic drug and it is marketed as tablet of strength 10mg. In this study an attempt is made to monitor the dissolution of Bepotastine Besilate tablet. Dissolution study was done for marketed sample using phosphate buffer 6.8, phosphate buffer 4.5 and 0.1 N HCl as dissolution media. Samples were analysed using UV spectrophotometer, HPLC and HPTLC. Detection wavelength selected was 226nm. A chromatographic separation is achieved on a C18 column with a mobile phase consisting of acetonitrile, water with isocratic elution with flow rate 1ml/min. Solvents used for development in HPTLC were chloroform and methanol. Percentage release of bepotastine besilate was calculated by extrapolation of calibration curve. The results of three analytical methods were compared by applying One-Way ANOVA. [ABSTRACT FROM AUTHOR]