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Depression and neurocognitive dysfunction in pediatric and young adult chronic kidney disease.
- Source :
- Pediatric Nephrology; Sep2019, Vol. 34 Issue 9, p1575-1582, 8p, 4 Charts
- Publication Year :
- 2019
-
Abstract
- Background: Depression affects 7–35% of children with chronic kidney disease (CKD), and in adults with CKD, the presence of depression links to poorer medical outcomes, social functioning difficulties, and neurocognitive impairments. The relationship between depression and neurocognitive function in youth with CKD is unclear. We sought to identify factors associated with depression in youth with CKD and to determine whether depression affects neurocognitive performance. Methods: We conducted cross-sectional analyses in 71 CKD and 64 control participants aged 8 to 25 years who completed depression inventories and neurocognitive assessments as part of the Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with CKD Study. In the CKD group, multivariable logistic regression analysis determined associations between clinical and demographic factors and depression. In the full study cohort, multivariable linear regression analyses, including an interaction term between CKD status and depression evaluated the effect of depression on 11 neurocognitive outcome domains. Results: Obesity significantly associated with depression in the CKD group (OR 10.25, P = 0.01). In adjusted analyses, depressed youth with CKD scored worse than non-depressed CKD participants by 0.6–1.0 standard deviations in 5 neurocognitive domains: attention, visual memory, visual-spatial, visual working memory, and problem solving. Conclusions: CKD youth with obesity are more likely to be depressed, and those who are depressed exhibit worse neurocognitive performance. Depression may represent a therapeutic target to improve neurocognitive performance in youth with CKD. [ABSTRACT FROM AUTHOR]
- Subjects :
- COGNITION disorder risk factors
MENTAL depression risk factors
CHRONIC kidney failure complications
OBESITY complications
ATTENTION
CHRONIC kidney failure
HEALTH status indicators
LONGITUDINAL method
MAGNETIC resonance imaging
MULTIVARIATE analysis
PROBLEM solving
RISK assessment
SPACE perception
VISUAL perception
MULTIPLE regression analysis
CROSS-sectional method
DESCRIPTIVE statistics
ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 34
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 137721313
- Full Text :
- https://doi.org/10.1007/s00467-019-04265-z