ESTIMATION OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN LOWER RESPIRATORY PEDIATRIC DISEASE.

Lower respiratory tract disease (LRT) a major public health problems with high mortality and one of the common causes of morbidity in children. Cytokines play a key role in the inflammatory process and pathogenesis of LRT disease. So the study aimed to detection the association between imbalance in pro- and anti-inflammatory biomarkers as cytokines (IL-6, TNF-á and IL-10) level and the development or progress some LRT disease such as bronchiolitis, bronchopneumonia and bronchial asthma. Case-control hospital study was performed of 100 patients with LRT disease in Baghdad Teaching Hospital in Baghdad city, Iraq with group of 30 healthy individual was used as control, the patients were divided according to types of disease into bronchiolitis 40 patients; bronchial asthma 38 patients and 22 patients suffering from pneumonia. The results revealed that percentage of male : female in both bronchiolitis and pneumonia was no significant different while the female were more than male in asthma and younger children more infected than aged children in LRT disease. The pro-inflammatory cytokine were increased in all diseases with higher level recorded in asthma then in bronchiolitis finally in pneumonia. In other hand the antiinflammatory cytokine appear that the asthma revealed high decreased then the bronchiolitis, finally the pneumonia. In conclusion, the imbalance in pro-inflammatory cytokine with increased their serum levels ,vs decreased the serum level of anti-inflammatory lead to persistence the inflammatory response and severity of respiratory disease. Also, the defect in cytokines level lead to increase the progression of LRT disease and can be consider as risk factor. [ABSTRACT FROM AUTHOR]