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Content validity and psychometric evaluation of Functional Assessment of Chronic Illness Therapy-Fatigue in patients with psoriatic arthritis.
- Source :
- Journal of Patient-Reported Outcomes; 1/24/2019, Vol. 3 Issue 1, pN.PAG-N.PAG, 1p
- Publication Year :
- 2019
-
Abstract
- Background: To evaluate the measurement properties (e.g. content validity, reliability and ability to detect change) of the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale in patients with active psoriatic arthritis (PsA). Methods: One-on-one semi-structured qualitative interviews with adult patients with active PsA evaluated the content validity of FACIT-Fatigue. Quantitative measurement properties were evaluated using data from phase III tofacitinib randomized controlled trials (RCTs) in PsA: OPAL Broaden (NCT01877668) and OPAL Beyond (NCT01882439). Results: Of 12 patients included in the qualitative study, 2 (17%) had mild, 8 (67%) had moderate, and 2 (17%) had severe PsA disease activity; 7 (58%) attributed fatigue to PsA, and 7 (58%) rated fatigue as important or extremely important. Most patients considered the FACIT-Fatigue items relevant to their PsA experience and understood item content and response options as intended. In the psychometric analysis of RCT data, a second-order confirmatory factor model fit the data well (Bentler's Comparative Fit Index ≥0.92). FACIT-Fatigue demonstrated good internal consistency (Cronbach's coefficient α ≥ 0.90), test-retest reliability (Intraclass Correlation Coefficient ≥ 0.80) and a strong correlation with SF-36 Vitality (r > 0.80). A robust relationship between disease activity (based on Patient's Global Assessment of Psoriasis and Arthritis) and FACIT-Fatigue was observed (effect sizes > 1.4), with clinically important difference for the FACIT-Fatigue total score estimated as 3.1 points, and the responder definition estimated as a 4-point improvement for FACIT-Fatigue total score. Conclusion: Fatigue was confirmed to be an important symptom to patients with PsA, and FACIT-Fatigue was found to be a reliable and valid measure in this population. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHRONIC diseases
PSORIATIC arthritis
RANDOMIZED controlled trials
STATISTICAL reliability
DATA analysis
CHRONIC disease treatment
CHRONIC diseases & psychology
RESEARCH evaluation
RESEARCH methodology evaluation
RESEARCH methodology
INTERVIEWING
QUANTITATIVE research
HEALTH surveys
PSYCHOMETRICS
FUNCTIONAL assessment
QUALITATIVE research
CRONBACH'S alpha
FACTOR analysis
INTRACLASS correlation
QUESTIONNAIRES
RESEARCH funding
FATIGUE (Physiology)
Subjects
Details
- Language :
- English
- ISSN :
- 25098020
- Volume :
- 3
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Patient-Reported Outcomes
- Publication Type :
- Academic Journal
- Accession number :
- 137442915
- Full Text :
- https://doi.org/10.1186/s41687-019-0094-5