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Emerging Treatment Targets for Migraine and Other Headaches.
- Source :
- Headache: The Journal of Head & Face Pain; Jul2019 Supplement S2, Vol. 59, p50-65, 16p, 1 Chart
- Publication Year :
- 2019
-
Abstract
- Migraine is a complex disorder that is characterized by an assortment of neurological and systemic effects. While headache is the most prominent feature of migraine, a host of symptoms affecting many physiological functions are also observed before, during, and after an attack. Furthermore, migraineurs are heterogeneous and have a wide range of responses to migraine therapies. The recent approval of calcitonin gene‐related‐peptide based therapies has opened up the treatment of migraine and generated a renewed interest in migraine research and discovery. Ongoing advances in migraine research have identified a number of other promising therapeutic targets for this disorder. In this review, we highlight emergent treatments within the following biological systems: pituitary adenylate cyclase activating peptdie, 2 non‐mu opioid receptors that have low abuse liability – the delta and kappa opioid receptors, orexin, and nitric oxide‐based therapies. Multiple mechanisms have been identified in the induction and maintenance of migraine symptoms; and this divergent set of targets have highly distinct biological effects. Increasing the mechanistic diversity of the migraine tool box will lead to more treatment options and better patient care. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00178748
- Volume :
- 59
- Database :
- Complementary Index
- Journal :
- Headache: The Journal of Head & Face Pain
- Publication Type :
- Academic Journal
- Accession number :
- 137414156
- Full Text :
- https://doi.org/10.1111/head.13585