Study of Mucin Histochemistry in Benign hyperplasia and Malignant Lesions of Human Prostate Gland.

Aim: Prostatic enlargement occurs due to nodular hyperplasia, prostatitis and neoplasm of prostate gland. Incidence of prostate cancer increases by 1% yearly which has been reported in the last three years. Early detection of prostate cancer is important. Also, the differentiation between benign hyperplasia and malignant lesions of prostate is very important for the treatment of patient. Aim of the present study is to evaluate the usefulness of Mucin stains in differentiating between benign hyperplasia and malignant lesions of prostate. Material and Methods: The study was done on ninety-five specimens of benign hyperplasia (n=73) and malignant (n=22) prostates which were collected from postmortem and surgically resected specimens in KIMSU and KHMRC hospital. Routine Hematoxylin & Eosin and special stains such as PAS, PAS-Diastase, PAS-Phenyl Hydrazine, Alcian Blue PH -2.5 and 1, Aldehyde Fuchsin, combined AB-PAS and AF-AB were performed. Results: We tabulated our results according to color intensity into different grades ranging from -ve to +++. Acid mucins were present predominantly in prostate carcinoma. Conclusion: Hence, mucin histochemistry may be a valuable and cost-effective tool for the differentiation between benign hyperplasia and carcinoma of prostate. [ABSTRACT FROM AUTHOR]