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Safety and efficacy of 125I brachytherapy for bilateral lung recurrences from hepatocellular carcinoma after resection or ablation.

Authors :
Xiang, Zhanwang
Bai, Mingjun
Li, Guohong
Zou, Bihui
Zhong, Zhihui
Gao, Fei
Wu, Chun
Huang, Mingsheng
Zhang, Fujun
Source :
Journal of Cancer Research & Clinical Oncology; Jul2019, Vol. 145 Issue 7, p1907-1916, 10p
Publication Year :
2019

Abstract

Purpose: To evaluate the safety and efficacy of <superscript>125</superscript>I brachytherapy to treat bilateral lung recurrences from hepatocellular carcinoma (HCC) after resection or ablation. Materials and methods: We retrospectively recruited 95 patients with bilateral lung recurrences from hepatocellular carcinoma (HCC) after resection or ablation who had received 3–6-month sorafenib with or without stereotactic body radiotherapy (SBRT), from October 2011 to January 2015; patients were then randomly divided into two groups, 44 patients received computed tomography (CT)-guided <superscript>125</superscript>I brachytherapy (group A), and 51 patients were treated with supportive and symptomatic treatments (group B). Results: The median survival time was 19 months (range of 3–36 months). The local response rate (LRR) at 3, 6, 12, 18, 24, 30 and 36 months in group A was 81.8%, 65.9%, 59.1%, 45.0%, 38.6%, 22.7%, 11.4%, respectively, and 64.7%, 47.1%, 33.3%, 25.4%, 15.7%, 11.7%, 7.8%, respectively, in group B (P < 0.05). The mean progression-free survival time (PFST) and overall survival (OS) of group A were significantly longer than those of group B. Alpha fetoprotein (AFP) and tumor size were independent factors that affected the PFST and OS, normal AFP levels and less than 1-cm tumor diameter had better PFST and OS (P < 0.05). No massive bleeding or serious complications occurred. Conclusion: CT-guided <superscript>125</superscript>I brachytherapy is safe and effective for the treatment of bilateral lung recurrences from HCC after resection or ablation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01715216
Volume :
145
Issue :
7
Database :
Complementary Index
Journal :
Journal of Cancer Research & Clinical Oncology
Publication Type :
Academic Journal
Accession number :
137015892
Full Text :
https://doi.org/10.1007/s00432-019-02943-x