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Behavioral Activity of Rats in Experimental Hypothyreosis and Its Correction with Iodine-Containing Drugs.

Authors :
Balakirev, N. A.
Deltsov, A. A.
Maksimov, V. I.
Kozlov, S. A.
Staroverova, I. N.
Source :
Russian Agricultural Sciences; Mar2019, Vol. 45 Issue 2, p212-215, 4p
Publication Year :
2019

Abstract

Abstract—Behavioral activity of rats in experimental hypothyreosis and its correction with iodine-containing drugs was investigated. It has been demonstrated that the administration of thyrostatic mercazolilum to white rats for 8 weeks leads to experimental hypothyreosis accompanied by a decrease in thyroxine (T4) level to 5.25 ng/mL and an increase in thyroid-stimulating hormone (TSH) level to 8.75 ng/mL. In the control (healthy) animals, the average levels of T4 and TSH were 43.70 and 1.73 ng/mL, respectively. When the animals with experimental hypothyreosis received an intramuscular injection of iodine-containing drugs (Sedimin-Fe<superscript>+</superscript> and Sedimin-Se<superscript>+</superscript>) twice with an interval of 10 days and a preparation of bio-iron with microelements orally for 20 days, the level of thyroxine rose to 52.7 ± 3.48 and 54.8 ± 4.17 ng/mL in response to Sedimin-Fe<superscript>+</superscript> and Sedimin-Se<superscript>+</superscript> administration, respectively, and to 56.2 ± 4.13 ng/mL after the ingestion of feed enriched with bio-iron and microelements. In animals that did not receive the drugs, the T4 level was 5.25 ± 0.55 ng/mL. The levels of thyroid-stimulating hormone after the treatment with iodine-containing preparations were 0.37 ± 0.14, 0.51 ± 0.18, 0.47 ± 0.15, and 8.75 ± 0.55 ng/mL for Sedimin-Fe<superscript>+</superscript>, Sedimin-Se<superscript>+</superscript>, bio-iron with microelements, and animals with experimental hypothyreosis, respectively. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10683674
Volume :
45
Issue :
2
Database :
Complementary Index
Journal :
Russian Agricultural Sciences
Publication Type :
Academic Journal
Accession number :
136891497
Full Text :
https://doi.org/10.3103/S1068367419020046