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The prognosis and changes of regional brain gray matter volume in MDD with gastrointestinal symptoms.
- Source :
- Neuropsychiatric Disease & Treatment; May2019, Vol. 15, p1181-1191, 11p
- Publication Year :
- 2019
-
Abstract
- aimed to investigate the basic clinical characteristics and regional GM volume changes in MDD accompanied by GI symptoms. Method: Patients with MDD (n=49) and age, gender, and educational level-matched healthy controls (n=30) were recruited. Patients with MDD were divided into two groups based on the GI status: MDD with (n=27) and without (n=22) GI symptoms. The 24-item Hamilton Depression Rating Scale (HAMD) was administered. T1-weighted anatomical images were obtained and analyzed. Correlation analysis was used to identify the possible associations between changed regional GM volume and GI symptoms and depressive symptoms. Results: The HAMD reductive ratio for 2 weeks of treatment in the GI symptoms group was significantly higher than the non-GI symptoms group (P<0.05). The regional GM volume showed significant differences among the three groups (Gaussian Random Field [GRF] correction, voxel-P<0.01, cluster-P <0.05). Compared with non-GI symptoms group, GI symptoms group exhibited significantly increased GM volume in the left hippocampus, left parahippocampal gyrus, right parahippocampal gyrus; and decreased GM volume in the right middle frontal gyrus, right precentral gyrus, right cuneus, right precuneus, right superior occipital gyrus (GRF correction, voxel-P <0.01, cluster-P <0.05). These altered brain areas were correlated with the GI symptoms, not depressive symptoms. Conclusion: The changed regional brain GM volume in GI-MDD group may be the pathogenesis for the GI symptoms. In addition, the GI symptoms may predict the prognosis of MDD. [ABSTRACT FROM AUTHOR]
- Subjects :
- MENTAL depression
HAMILTON Depression Inventory
RANDOM fields
Subjects
Details
- Language :
- English
- ISSN :
- 11766328
- Volume :
- 15
- Database :
- Complementary Index
- Journal :
- Neuropsychiatric Disease & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 136888585
- Full Text :
- https://doi.org/10.2147/NDT.S197351