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Direct writing of optical microresonators in a lab-on-a-chip for label-free biosensing.
- Source :
- Lab on a Chip; 6/7/2019, Vol. 19 Issue 11, p1985-1990, 6p
- Publication Year :
- 2019
-
Abstract
- Whispering gallery mode (WGM) resonators are promising optical structures for microfluidic label-free biosensors mainly due to their high sensitivity, but from a practical point of view they present numerous constraints that make their use in real laboratory diagnosis application difficult. Herein we report on a monolithic lab on a chip fabricated by a hybrid femtosecond laser micromachining approach, for label-free biosensing. It consists of a polymer WGM microresonator sensor integrated inside a glass microfluidic chip, presenting a refractive index change sensitivity of 61 nm per RIU. The biosensing capabilities of the device have been demonstrated by exploiting the biotin–streptavidin binding affinity, obtaining a measurable minimum surface density increase of 67 × 10<superscript>3</superscript> molecules per μm<superscript>2</superscript>. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14730197
- Volume :
- 19
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Lab on a Chip
- Publication Type :
- Academic Journal
- Accession number :
- 136691942
- Full Text :
- https://doi.org/10.1039/c9lc00174c