Functional interaction between InsP3 receptors and store-operated Htrp3 channels.

Authors :: Kiselyov, Kirill
Xin Xu
Mozhayeva, Galina
Tuan Kuo
Pessah, Isaac
Mignery, Gregory
Xi Zhu
Birnbaumer, Lutz
Mualiem, Shmuel
Source :: Nature; 12/3/1998, Vol. 396 Issue 6710, p478, 5p, 4 Diagrams, 33 Graphs
Publication Year :: 1998
Abstract: Presents research which studied the mammalian Htrp3 protein and the effect of Ca2+ store depletion on store-operated channels (SOCs) and the Ca2+-release-activated current (Icrac). Release of calcium ions from intracellular stores; Effects of the depletion of Ca2+; Models of cell signaling; Expression of Htrp3 channels in HEK293 cells; Activation of Htrp3 channels by InsP3; Evidence for the coupling hypothesis.

Subjects :: PROTEINS
CALCIUM ions
ION channels
CELLULAR control mechanisms
METABOLISM
PHYSIOLOGY

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