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ω-Aryloxy Analogs of Prostamides.
- Source :
- Russian Journal of Organic Chemistry; Apr2019, Vol. 55 Issue 4, p498-501, 4p, 3 Diagrams
- Publication Year :
- 2019
-
Abstract
- Acylation of cloprostenol with acetic anhydride in pyridine, followed by treatment of the exhaustive acetylation product with water, gave 9,11,15-triacetoxy derivative whose reaction with 1,1′-carbonyldiimidazole afforded the corresponding imidazolide. The subsequent condensation with 2-aminoethanol and removal of acetate protecting group lead to the formation of N-(2-hydroxyethyl) cloprostenol amide. Analogous N-ethyl amide was synthesized by reaction of cloprostenol methyl ester with aqueous ethylamine. [ABSTRACT FROM AUTHOR]
- Subjects :
- METHYL formate
ACETIC anhydride
ACYLATION
GROUP formation
ACETYLATION
DEACETYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 10704280
- Volume :
- 55
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Russian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 136662655
- Full Text :
- https://doi.org/10.1134/S1070428019040134