2-Amino-2,6-Dideoxy-D-Glucose (D-Quinovosamine): a Constituent of the Lipopolysaccharide of <em>Vibrio cholerae</em>.

From the lipopolysaccharides of Vibrio cholerae strains Inaba and Ogawa, an unusual amino sugar was isolated. By sequential oxidation with sodium metaperiodate and hypoiodide and by oxidation with periodate followed by detection of the acetaldehyde formed, the amino sugar was characterized as a 2-amino-dideoxyaldose. The hydroehloride of the amino sugar was compared with those of 2-amino-2,6-dideoxy-D-glucose, 2-amino-2,6-dideoxy-L-galactose, 2-amino-2,6-dideoxy-D-mannose, 2-amino-2,6.di-deoxy-D-gulose, and 2-amino-2,6-dideoxy-D-allose in an amino acid analyzer. The amino sugar alcohols were studied by paper electrophoresis in molybdats buffer. From the results obtained the amino sugar was identified as 2.amino-2,6-dideoxyglucose (quinovosamine). Its optical rotation indicated it to be of the D-configuration. [ABSTRACT FROM AUTHOR]