Back to Search Start Over

Intra‐ and inter‐site reproducibility of human brain single‐voxel proton MRS at 3 T.

Authors :
Graf, Carina
MacMillan, Erin L.
Fu, Eric
Harris, Trudy
Traboulsee, Anthony
Vavasour, Irene M.
MacKay, Alex L.
Mädler, Burkhard
Li, David K.B.
Laule, Cornelia
Source :
NMR in Biomedicine; Jun2019, Vol. 32 Issue 6, pN.PAG-N.PAG, 1p
Publication Year :
2019

Abstract

Introduction: Clinical trials that involve participants from multiple sites necessitate standardized and reliable quantitative MRI outcomes to detect significant group differences over time. Metabolite concentrations measured by proton MRS (1H‐MRS) provide valuable information about in vivo metabolism of the central nervous system, but can vary based on the acquisition and quantitation methods used by different MR sites. Therefore, we investigated the intra‐ and inter‐site reproducibility of metabolite concentrations measured by 1H‐MRS on MRI scanners from a single manufacturer across six sites. Methods: Five healthy controls were scanned twice within 24 h at six participating 3 T MR sites with large single‐voxel PRESS (TE/TR/NSA = 36 ms/4000 ms/56) and anatomical images for voxel positioning and correction of partial volume relaxation. Absolute metabolite concentrations were calculated relative to the T1 and T2 relaxation corrected signal from water. Intra‐ and inter‐site reproducibility was assessed using Bland–Altman plots and intra‐ and inter‐site coefficient of variation (CoV) as well as intra‐ and inter‐site intra‐class correlation coefficient. Results: The median intra‐site CoVs for the five major metabolite concentrations ([NAA], [tCr], [Glu], [tCho] and [Ins]) were between 2.5 and 5.3%. Inter‐site CoVs were also low, with the median CoVs for all metabolites between 3.7 and 6.4%. Metabolite concentrations were robust to small inconsistencies in voxel placement and site was not the driving factor in the variance of the measurement of any metabolite concentration. Between‐subject differences accounted for the majority of the concentration variability for creatine, choline and myo‐inositol (42–65% of the variance). Conclusion: A large single‐voxel 1H‐MRS acquisition from a single manufacturer's MRI scanner is highly reproducible and reliable for multi‐site clinical trials. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09523480
Volume :
32
Issue :
6
Database :
Complementary Index
Journal :
NMR in Biomedicine
Publication Type :
Academic Journal
Accession number :
136497355
Full Text :
https://doi.org/10.1002/nbm.4083