The primary immune response of mice to two submucosal antigens.

Within the limits of these experiments there appeared to be a difference in quality of the immune response of mice to Bovine Serum Albumin and Horse Ferritin. A primary injection of Bovine Serum Albumin in the mandibular labial sulcus was followed by cell replication and plasma cell differentiation in the cervical lymph nodes and a rise in serum antibody. No similar quantitatively measurable cellular response was found in the cervical lymph nodes to a primary injection of Horse Ferritin in the same site, although detectable quantities of serum antibody were present in the same animals. [ABSTRACT FROM AUTHOR]