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Drug Treatment of Hyperlipidemia in Chinese Patients: Focus on the Use of Simvastatin and Ezetimibe Alone and in Combination.
- Source :
- American Journal of Cardiovascular Drugs; Jun2019, Vol. 19 Issue 3, p237-247, 11p
- Publication Year :
- 2019
-
Abstract
- Elevated serum low-density lipoprotein cholesterol (LDL-C) is a major risk factor for coronary heart disease (CHD). Many guidelines recommend LDL-C as a primary treatment target, and statins represent the cornerstone of treatment for lipid management. Recently revised guidelines recommend even more intense management of LDL-C, especially in patients at moderate and high risk. However, LDL-C levels in the Chinese population differ from those in Western populations, and the benefits and safety of the maximum allowable dose of statins have yet to be determined. Furthermore, in practice, many patients do not achieve the increasingly stringent LDL-C goals. Consequently, alternative approaches to lipid management are required. Combination therapy with ezetimibe and a statin, which have complementary mechanisms of action, is more effective than statin monotherapies, even at high doses. Several clinical studies have consistently shown that combination therapy with ezetimibe and simvastatin lowers LDL-C more potently than statin monotherapies. Moreover, the safety and tolerability profile of the combination therapy appears to be similar to that of low-dose statin monotherapies. This review discusses the role of simvastatin in combination with ezetimibe in controlling dyslipidemia in Chinese patients, particularly the efficacy and safety of combination therapy in light of recently published clinical data. [ABSTRACT FROM AUTHOR]
- Subjects :
- CORONARY heart disease risk factors
DRUG therapy for hyperlipidemia
EZETIMIBE
SIMVASTATIN
COMBINATION drug therapy
CHINESE people
CLINICAL medicine
DRUG tolerance
HYPERLIPIDEMIA
LOW density lipoproteins
EVALUATION of medical care
MEDICAL protocols
PATIENT safety
RACE
TREATMENT effectiveness
DISEASE complications
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 11753277
- Volume :
- 19
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- American Journal of Cardiovascular Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 136338040
- Full Text :
- https://doi.org/10.1007/s40256-018-00317-1