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Anti-tumor effects of lidocaine on human gastric cancer cells in vitro.
- Source :
- Bratislava Medical Journal / Bratislavské Lekárske Listy; 2019, Vol. 120 Issue 3, p212-217, 6p
- Publication Year :
- 2019
-
Abstract
- Currently, there exists an urgent need to investigate the anti-cancer effects of lidocaine on gastric cancer cells. The purpose of the present study was to evaluate the anti-tumor effects and the underlying mechanisms of lidocaine in gastric cancer cells. Our results indicated that lidocaine significantly suppressed proliferation, migration and invasion and induced apoptosis in a dose-dependently manner in human gastric cancer cells. In addition, our data shown that the expression of Bcl-2 was decreased and the level of Bax was increased by lidocaine treatment. Furthermore, we found that lidocaine altered the protein expression of the MAPK pathway. p-p38 was also increased simultaneously, while the level of p38 was not changed. In summary, lidocaine has a prominent anti-tumor activity on gastric cancer cells and is a promising therapeutic agent for the treatment of gastric cancer (Fig. 4, Ref. 32). [ABSTRACT FROM AUTHOR]
- Subjects :
- STOMACH cancer
CANCER cells
LIDOCAINE
ANTINEOPLASTIC agents
PROTEIN expression
Subjects
Details
- Language :
- English
- ISSN :
- 00069248
- Volume :
- 120
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Bratislava Medical Journal / Bratislavské Lekárske Listy
- Publication Type :
- Academic Journal
- Accession number :
- 136139783
- Full Text :
- https://doi.org/10.4149/BLL_2019_036