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Stressful Newborn Memories: Pre-Conceptual, In Utero , and Postnatal Events.

Authors :
Papadopoulou, Zoe
Vlaikou, Angeliki-Maria
Theodoridou, Daniela
Markopoulos, Georgios S.
Tsoni, Konstantina
Agakidou, Eleni
Drosou-Agakidou, Vasiliki
Turck, Christoph W.
Filiou, Michaela D.
Syrrou, Maria
Source :
Frontiers in Psychiatry; 4/18/2019, pN.PAG-N.PAG, 9p
Publication Year :
2019

Abstract

Early-life stressful experiences are critical for plasticity and development, shaping adult neuroendocrine response and future health. Stress response is mediated by the autonomous nervous system and the hypothalamic–pituitary–adrenal (HPA) axis while various environmental stimuli are encoded via epigenetic marks. The stress response system maintains homeostasis by regulating adaptation to the environmental changes. Pre-conceptual and in utero stressors form the fetal epigenetic profile together with the individual genetic profile, providing the background for individual stress response, vulnerability, or resilience. Postnatal and adult stressful experiences may act as the definitive switch. This review addresses the issue of how preconceptual in utero and postnatal events, together with individual differences, shape future stress responses. Putative markers of early-life adverse effects such as prematurity and low birth weight are emphasized, and the epigenetic, mitochondrial, and genomic architecture regulation of such events are discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16640640
Database :
Complementary Index
Journal :
Frontiers in Psychiatry
Publication Type :
Academic Journal
Accession number :
135966049
Full Text :
https://doi.org/10.3389/fpsyt.2019.00220