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Clinical proof of concept for a safe and effective NF‐κB‐targeting strategy in multiple myeloma.

Authors :
Tornatore, Laura
Capece, Daria
D'Andrea, Daniel
Begalli, Federica
Verzella, Daniela
Bennett, Jason
Bannoo, Selina
Franzoso, Guido
Chambery, Angela
Oblak, Metod
Al‐Obaidi, Magda J.
Gabriel, Ian
Kaczmarski, Richard S.
Oakervee, Heather E.
Kaiser, Martin F.
Wechalekar, Ashutosh
Benjamin, Reuben
Apperley, Jane F.
Auner, Holger W.
Acton, Gary
Source :
British Journal of Haematology; May2019, Vol. 185 Issue 3, p588-592, 5p, 2 Graphs
Publication Year :
2019

Abstract

The article focuses on the efficiency of the nuclear factor (NF)-ΚB pathway in the treatment of multiple myeloma (MM). It talks about the pathway treatment strategy despite being efficient has not yet been approved in the pharmaceutical industry due to the associated toxicities. It tells about alternative agents like the immunomodulatory drugs and proteasome inhibitors are unable to specifically target the cancer cells in the body.

Subjects

Subjects :
MULTIPLE myeloma
PROOF of concept

Details

Language :
English
ISSN :
00071048
Volume :
185
Issue :
3
Database :
Complementary Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
135934104
Full Text :
https://doi.org/10.1111/bjh.15569