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Piper novae-hollandiae Miq. Leaf Extracts Lack Antibacterial Activity and are non-toxic in vitro.
- Source :
- Pharmacognosy Communications; Apr-Jun2019, Vol. 9 Issue 2, p75-79, 5p
- Publication Year :
- 2019
-
Abstract
- Introduction: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a genus are known to possess therapeutic properties. The genus Piper has a long history of medicinal usage in many areas of the world. Many Piper spp. are known to have therapeutic properties and several have antibacterial bioactivities. Methods: The ability of P. novae-hollandiae leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: P. novae-hollandiae methanolic and aqueous extracts were completely ineffective at inhibiting the growth of panels of gram-positive and gram-negative bacteria. The extracts were nontoxic or of low toxicity to Artemia nauplii following 24 h exposure. Conclusion: Despite the close taxonomic relationship with several bioactive Piper spp. and its therapeutic use by first Australians, P. novae-hollandiae leaf extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is warranted. [ABSTRACT FROM AUTHOR]
- Subjects :
- PIPER (Genus)
BACTERIAL growth
EXTRACTS
METABOLITES
GRAM-negative bacteria
Subjects
Details
- Language :
- English
- ISSN :
- 22490159
- Volume :
- 9
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Pharmacognosy Communications
- Publication Type :
- Academic Journal
- Accession number :
- 135902817
- Full Text :
- https://doi.org/10.5530/pc.2019.2.14