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High Constitutive Interleukin 10 Level Interferes With the Immune Response to Varicella-Zoster Virus in Elderly Recipients of Live Attenuated Zoster Vaccine.
- Source :
- Journal of Infectious Diseases; 4/15/2019, Vol. 219 Issue 8, p1338-1346, 9p
- Publication Year :
- 2019
-
Abstract
- <bold>Introduction: </bold>Live attenuated zoster vaccine (Zostavax) was used to test the hypothesis that constitutive level of interleukin 10 (IL-10), which may be high in elderly subjects, impairs vaccine efficacy. If constitutive IL-10 impairs vaccine efficacy, the effectiveness of viral vaccines might be improved by transient inhibition of IL-10 before vaccination.<bold>Methods: </bold>Zostavax was given to 26 patients (age, 60-80 years). IL-10 and immunity to varicella zoster virus (VZV) were measured at baseline and after vaccination. Fluorescent antibody to membrane antigen (FAMA) assays and glycoprotein enzyme-linked immunosorbent assays (gpELISAs) were used to assess humoral immunity; anti-varicella virus T-cell responses were studied in a subset of subjects. In a prospective animal model, T-cell responses to chimeric vaccines against lymphocytic choriomeningitis virus (LCMV) were assessed in mice that express or lack IL-10.<bold>Results: </bold>FAMA assays revealed significant boosting (by 4-fold) of humoral immunity, which occurred only in subjects (10 of 26) with a low constitutive IL-10 level (ie, <20 pg/mL); moreover, the Zostavax-induced FAMA and gpELISA responses were inversely related to the constitutive IL-10 level. Significant VZV-specific T-cell responses followed vaccination only in subjects with a low constitutive IL-10 level. Vaccine-induced LCMV-specific T-cell responses in mice lacking IL-10 were greater than in wild-type animals.<bold>Conclusions: </bold>A high constitutive IL-10 level adversely affects vaccine efficacy. [ABSTRACT FROM AUTHOR]
- Subjects :
- HERPES zoster vaccines
IMMUNE response
VARICELLA-zoster virus
LYMPHOCYTIC choriomeningitis virus
VACCINE effectiveness
VIRAL vaccines
ANIMAL experimentation
COMPARATIVE studies
ENZYME-linked immunosorbent assay
FLUORESCENT antibody technique
HERPESVIRUSES
INTERLEUKINS
RESEARCH methodology
MEDICAL cooperation
MICE
RESEARCH
EVALUATION research
ANTIBODY formation
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 219
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 135845550
- Full Text :
- https://doi.org/10.1093/infdis/jiy660