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Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans.
- Source :
- European Journal of Nuclear Medicine & Molecular Imaging; May2019, Vol. 46 Issue 5, p1175-1178, 4p, 1 Chart, 1 Graph
- Publication Year :
- 2019
-
Abstract
- Purpose: To determine how the low-affinity (Z)-isomer of the radiotracer [<superscript>11</superscript>C]ABP688 affects binding potential values in vivo in humans. Methods: High-resolution [<superscript>11</superscript>C]ABP688 PET scans were acquired on 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). The relative contents of (E)- and (Z)-isomers were determined prior to injection using analytical high-performance liquid chromatography [r<subscript>t</subscript>(E) = 10 min, r<subscript>t</subscript>(Z) = 8.5 min]. Mean binding potential [BP<subscript>ND</subscript> = f<subscript>ND</subscript> * (B<subscript>avail</subscript>/K<subscript>D</subscript>)] values were calculated in the striatum, limbic regions, and prefrontal cortex using the simplified reference tissue model with cerebellar grey matter as reference. Results: Mean ± SD (E)-isomer content in [<superscript>11</superscript>C]ABP688 production was 92 ± 3.8% (range 78–97%). Percent (E)-isomer was positively correlated with BP<subscript>ND</subscript> in the striatum (ρ = 0.28, p = 0.015) and limbic regions (ρ = 0.25, p = 0.036). In multiple regression analysis, sex (β = 0.39, p = 0.001) and (E)-isomer content (β = 0.23, p = 0.040) were significant predictors of BP<subscript>ND</subscript>. Conclusions: Even modest levels of (Z)-[<superscript>11</superscript>C]ABP688 can reduce estimates of tracer binding in vivo. Future studies should use production methods that enrich levels of (E)-[<superscript>11</superscript>C]ABP688, report tracer isomer ratios, and account for this factor in their analyses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 46
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 135780318
- Full Text :
- https://doi.org/10.1007/s00259-018-4237-3