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Cancer Chemotherapy: Redox‐Responsive Dual Drug Delivery Nanosystem Suppresses Cancer Repopulation by Abrogating Doxorubicin‐Promoted Cancer Stemness, Metastasis, and Drug Resistance (Adv. Sci. 7/2019).

Authors :
Liu, Jia
Chang, Bingcheng
Li, Qilin
Xu, Luming
Liu, Xingxin
Wang, Guobin
Wang, Zheng
Wang, Lin
Source :
Advanced Science; 4/3/2019, Vol. 6 Issue 7, pN.PAG-N.PAG, 1p
Publication Year :
2019

Abstract

Chemotherapy effectiveness is greatly challenged by chemodrugs' intrinsic pathological interactions with tumor cells, which enhance cancer stemness, invasiveness and acquired drug resistance. In article number 1801987, Guobin Wang, Zheng Wang, Lin Wang, and co‐workers construct a redox‐responsive, celecoxib‐modified nanosystem that efficiently enhances doxorubicin‐based chemotherapy and suppresses cancer repopulation by abrogating doxorubicin‐induced enhancement of cancer stemness, metastasis and drug resistance. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
21983844
Volume :
6
Issue :
7
Database :
Complementary Index
Journal :
Advanced Science
Publication Type :
Academic Journal
Accession number :
135709827
Full Text :
https://doi.org/10.1002/advs.201970043