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Anemia Is a Novel Predictive Factor for the Onset of Severe Chemotherapy-Induced Peripheral Neuropathy in Lymphoma Patients Receiving Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone Therapy.
- Source :
- Oncology Research; 2019, Vol. 27 Issue 4, p469-474, 6p
- Publication Year :
- 2019
-
Abstract
- Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed a retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Forty patients (indolent lymphoma, n=9; diffuse large B-cell lymphoma; n=31) received R-CHOP therapy from September 2009 to July 2014. The median age of patients was 58 years (range=27-76 years). Statistical analyses were applied to the patients, who were divided into two groups: mild CIPN (no symptoms or grade 1 according to the CTCAE version 3.0 program) and severe CIPN patients (grade 2 or higher). Forward stepwise logistic regression analyses were performed using the following variables: sex, BMI, BSA, hyperglycemia, malnutrition, and anemia. Severe CIPN occurred in seven patients (17.5%). Gender and anemia remained following the stepwise procedure, and anemia predicted severe CIPN significantly (OR=19.45, 95% confidence interval=1.52-171.12). Our study suggests that anemia at initial diagnosis could be a predictive factor of R-CHOP-induced CIPN. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09650407
- Volume :
- 27
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Oncology Research
- Publication Type :
- Academic Journal
- Accession number :
- 135615655
- Full Text :
- https://doi.org/10.3727/096504018X15267574931782