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An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms.
- Source :
- Chemical Communications; 4/4/2019, Vol. 55 Issue 26, p3833-3836, 4p
- Publication Year :
- 2019
-
Abstract
- Multidrug resistance mediated by the overexpression of ABC transporters is a major challenge in cancer chemotherapy. Here, we report the synthesis of an organoruthenium complex, RuF, that was designed to surmount multidrug resistance by combining ABCG2 inhibition and cancer cell cytotoxicity, yielding synergistic efficacy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 26
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 135587133
- Full Text :
- https://doi.org/10.1039/c9cc00882a