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Crystal Structure of the PX Domain of SNX27.
- Source :
- Biochemistry (00062979); Feb2019, Vol. 84 Issue 2, p147-152, 6p
- Publication Year :
- 2019
-
Abstract
- SNX27 is a component of the retromer complex essential for the recycling of transmembrane receptors. SNX27 contains the N-terminal Phox (PX) domain that binds inositol 1,3-diphosphate (Ins(1,3)P<subscript>2</subscript>) and is important for the SNX27 localization. Here, we determined the crystal structure of human SNX27 PX domain by X-ray crystallography. We found that the sulfate ion is located in the positively charged lipid-binding pocket of the PX domain, which mimics the phospholipid recognition. In addition, we modelled the SNX27-PX–Ins(1,3)P<subscript>2</subscript> complex to better understand the mechanism of Ins(1,3)P<subscript>2</subscript> recognition by the PX domain of SNX27. [ABSTRACT FROM AUTHOR]
- Subjects :
- CRYSTAL structure
X-ray crystallography
Subjects
Details
- Language :
- English
- ISSN :
- 00062979
- Volume :
- 84
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Biochemistry (00062979)
- Publication Type :
- Academic Journal
- Accession number :
- 135580276
- Full Text :
- https://doi.org/10.1134/S0006297919020056