Synthesis and Anticoagulant Bioactivity of Heterocyclic Derivatives of Resveratrol.

Twenty-five resveratrol derivatives were synthesized, among which eight compounds have not yet been reported. The target compounds were evaluated for thrombin inhibitory activity in vitro (IC₅₀). The results showed that four compounds displayed a better thrombin inhibitory activity with IC₅₀ values from 10.43 to 18.31 μM, better than resveratrol (25.87 μM). The R₃ position of resveratrol was modified by heterocyclic rings containing oxygen and sulfur, which could increase the anticoagulant activity of resveratrol. [ABSTRACT FROM AUTHOR]