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Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration.

Authors :
Hu, Nan‐Xi
Chen, Mei
Liu, Yi‐Song
Shi, Qi
Yang, Bo
Zhang, Huan‐Cheng
Cheng, Pi
Tang, Qi
Liu, Zhao‐Ying
Zeng, Jian‐Guo
Source :
Journal of Veterinary Pharmacology & Therapeutics; Mar2019, Vol. 42 Issue 2, p197-206, 10p
Publication Year :
2019

Abstract

Sanguinarine (SA) and chelerythrine (CHE) are the main active components of the phytogenic livestock feed additive, Sangrovit®. However, little information is available on the pharmacokinetics of Sangrovit® in poultry. The goal of this work was to study the pharmacokinetics of SA, CHE, and their metabolites, dihydrosanguinarine (DHSA) and dihydrochelerythrine (DHCHE), in 10 healthy female broiler chickens following oral (p.o.) administration of Sangrovit® and intravenous (i.v.) administration of a mixture of SA and CHE. The plasma samples were processed using two different simple protein precipitation methods because the parent drugs and metabolites are stable under different pH conditions. The absorption and metabolism of SA following p.o. administration were fast, with half‐life (t1/2) values of 1.05 ± 0.18 hr and 0.83 ± 0.10 hr for SA and DHSA, respectively. The maximum concentration (Cmax) of DHSA (2.49 ± 1.4 μg/L) was higher that of SA (1.89 ± 0.8 μg/L). The area under the concentration vs. time curve (AUC) values for SA and DHSA were 9.92 ± 5.4 and 6.08 ± 3.49 ng/ml hr, respectively. Following i.v. administration, the clearance (CL) of SA was 6.79 ± 0.63 (L·h−1·kg−1) with a t1/2 of 0.34 ± 0.13 hr. The AUC values for DHSA and DHCHE were 7.48 ± 1.05 and 0.52 ± 0.09 (ng/ml hr), respectively. These data suggested that Sangrovit® had low absorption and bioavailability in broiler chickens. The work reported here provides useful information on the pharmacokinetic behavior of Sangrovit® after p.o. and i.v. administration in broiler chickens, which is important for the evaluation of its use in poultry. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01407783
Volume :
42
Issue :
2
Database :
Complementary Index
Journal :
Journal of Veterinary Pharmacology & Therapeutics
Publication Type :
Academic Journal
Accession number :
135035976
Full Text :
https://doi.org/10.1111/jvp.12729