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MicroRNA-761 is downregulated in colorectal cancer and regulates tumor progression by targeting Rab3D.
- Source :
- Experimental & Therapeutic Medicine; Mar2019, Vol. 17 Issue 3, p1841-1846, 6p
- Publication Year :
- 2019
-
Abstract
- The purpose of the present study was to investigate the biological role of microRNA-761 (miR-761) in colorectal cancer (CRC) and the underlying mechanisms by which miR-761 regulates CRC cell proliferation and migration. Quantitative polymerase chain reaction was performed to measure miR-761 expression in CRC tumor tissues and cell lines. It was demonstrated that miR-761 expression was dramatically reduced in CRC tumor tissues and cell lines compared with in normal tissues and cell lines. Overexpression of miR-761 significantly decreased CRC cell growth and migration. Using bioinformatics analysis and luciferase reporter assays, Rab3D was identified as a novel target of miR-761. In addition, it was demonstrated that Rab3D expression was negatively correlated with miR-761. Furthermore, overexpression of Rab3D could reverse the inhibitory effects of miR-761 on cell proliferation and migration. Collectively, the present study demonstrated that miR-761 overexpression could inhibit the proliferation and migration of CRC cell lines, partly at least, via directly targeting Rab3D. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELL migration
COLORECTAL cancer
CELL growth
CELL proliferation
CELL lines
Subjects
Details
- Language :
- English
- ISSN :
- 17920981
- Volume :
- 17
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Experimental & Therapeutic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 135034966