Back to Search
Start Over
Heart failure with preserved ejection fraction in Asia.
- Source :
- European Journal of Heart Failure; Jan2019, Vol. 21 Issue 1, p23-36, 14p, 5 Charts, 4 Graphs
- Publication Year :
- 2019
-
Abstract
- <bold>Background: </bold>Heart failure with preserved ejection fraction (HFpEF) is a global public health problem. Unfortunately, little is known about HFpEF across Asia.<bold>Methods and Results: </bold>We prospectively studied clinical characteristics, echocardiographic parameters and outcomes in 1204 patients with HFpEF (left ventricular ejection fraction ≥50%) from 11 Asian regions, grouped as Northeast Asia (Hong Kong, Taiwan, China, Japan, Korea, n = 543), South Asia (India, n = 252), and Southeast Asia (Malaysia, Thailand, Singapore, Indonesia, Philippines, n = 409). Mean age was 68 ±12 years (37% were < 65 years) and 50% were women. Seventy per cent of patients had ≥2 co-morbidities, most commonly hypertension (71%), followed by anaemia (57%), chronic kidney disease (50%), diabetes (45%), coronary artery disease (29%), atrial fibrillation (29%) and obesity (26%). Southeast Asian patients had the highest prevalence of all co-morbidities except atrial fibrillation, South Asians had the lowest prevalence of all co-morbidities except anaemia and obesity, and Northeast Asians had more atrial fibrillation. Left ventricular hypertrophy and concentric remodelling were most prominent among Southeast and South Asians, respectively (P < 0.001). Overall, 12.1% of patients died or were hospitalized for heart failure within 1 year. Southeast Asians were at higher risk for adverse outcomes, independent of co-morbidity burden and cardiac geometry.<bold>Conclusion: </bold>These first prospective multinational data from Asia show that HFpEF affects relatively young patients with a high burden of co-morbidities. Regional differences in types of co-morbidities, cardiac remodelling and outcomes of HFpEF across Asia have important implications for public health measures and global HFpEF trial design. [ABSTRACT FROM AUTHOR]
- Subjects :
- LEFT ventricular hypertrophy
HEART failure
VENTRICULAR ejection fraction
KIDNEY diseases
HEART
COMPARATIVE studies
ECHOCARDIOGRAPHY
LEFT heart ventricle
HEART physiology
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
PUBLIC health
RESEARCH
COMORBIDITY
EVALUATION research
DISEASE prevalence
STROKE volume (Cardiac output)
Subjects
Details
- Language :
- English
- ISSN :
- 13889842
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Heart Failure
- Publication Type :
- Academic Journal
- Accession number :
- 134603239
- Full Text :
- https://doi.org/10.1002/ejhf.1227