Gold Catalysis in (Supra)Molecular Cages to Control Reactivity and Selectivity.

Gold catalysis has experienced a tremendous development over the past decades, and is nowadays widely used in organic synthesis to perform chemical transformations of π‐bond‐containing molecules. Catalyst development has been based mostly on ligand development and counter‐ion strategies. More recently, the encapsulation of gold catalysts in (supra)molecular cages was explored as a new way to control selectivity and reactivity of gold catalysts. In this review, we describe the cages that have been employed as hosts for gold complexes, along with their impact on the catalytic performance. Covalent and supramolecular approaches to encapsulate single metal complexes will be described and the impact on the catalytic performance will be discussed. Also, recent strategies to pre‐organize multiple metal centers will be discussed. C‐Au‐ght! Recent advances in gold catalysis in (supra)molecular cages allow control of the reactivity, selectivity and enhanced stability of gold complexes. Both covalent and supramolecular strategies are reviewed and special features of each systems are highlighted. [ABSTRACT FROM AUTHOR]