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Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.
- Source :
- Scientific Reports; 2/6/2019, Vol. 9 Issue 1, p1-1, 1p
- Publication Year :
- 2019
-
Abstract
- Immune reconstitution inflammatory syndrome (IRIS) occurs in up to 40% of individuals co-infected with pulmonary tuberculosis (PTB) and HIV, primarily upon antiretroviral therapy (ART) initiation. Phenotypic changes in T-cells during TB-IRIS and their relationship with systemic inflammation are not fully understood. In this prospective cohort study, we followed 48 HIV-positive patients with PTB from South India before and after ART initiation, examining T-lymphocyte subsets and inflammatory biomarkers in peripheral blood. Quantification of naïve (CD27<superscript>+</superscript>CD45RO<superscript>−</superscript>) as well as effector memory CD4<superscript>+</superscript> T cells (CD27<superscript>−</superscript>CD45RO<superscript>+</superscript>) at weeks 2-6 after ART initiation could distinguish TB-IRIS from non-IRIS individuals. Additional analyses revealed that ART reconstituted different quantities of CD4<superscript>+</superscript> T lymphocyte subsets with preferential expansion of CXCR3<superscript>+</superscript> CCR6<superscript>−</superscript> cells in TB-IRIS patients. Moreover, there was an expansion and functional restoration of central memory (CD27<superscript>+</superscript>CD45RO<superscript>+</superscript>) CXCR3<superscript>+</superscript>CCR6<superscript>−</superscript> CD4<superscript>+</superscript> lymphocytes and corresponding cytokines, with reduction in CXCR3<superscript>−</superscript>CCR6<superscript>+</superscript> cells after ART initiation only in those who developed TB-IRIS. Together, these observations trace a detailed picture of CD4<superscript>+</superscript> T cell subsets tightly associated with IRIS, which may serve as targets for prophylactic and/or therapeutic interventions in the future. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 134563089
- Full Text :
- https://doi.org/10.1038/s41598-018-37846-3