Back to Search Start Over

Apollo: Democratizing genome annotation.

Authors :
Dunn, Nathan A.
Unni, Deepak R.
Diesh, Colin
Munoz-Torres, Monica
Harris, Nomi L.
Yao, Eric
Rasche, Helena
Holmes, Ian H.
Elsik, Christine G.
Lewis, Suzanna E.
Source :
PLoS Computational Biology; 2/6/2019, Vol. 15 Issue 2, p1-14, 14p, 3 Color Photographs, 2 Diagrams
Publication Year :
2019

Abstract

Genome annotation is the process of identifying the location and function of a genome's encoded features. Improving the biological accuracy of annotation is a complex and iterative process requiring researchers to review and incorporate multiple sources of information such as transcriptome alignments, predictive models based on sequence profiles, and comparisons to features found in related organisms. Because rapidly decreasing costs are enabling an ever-growing number of scientists to incorporate sequencing as a routine laboratory technique, there is widespread demand for tools that can assist in the deliberative analytical review of genomic information. To this end, we present Apollo, an open source software package that enables researchers to efficiently inspect and refine the precise structure and role of genomic features in a graphical browser-based platform. Some of Apollo’s newer user interface features include support for real-time collaboration, allowing distributed users to simultaneously edit the same encoded features while also instantly seeing the updates made by other researchers on the same region in a manner similar to Google Docs. Its technical architecture enables Apollo to be integrated into multiple existing genomic analysis pipelines and heterogeneous laboratory workflow platforms. Finally, we consider the implications that Apollo and related applications may have on how the results of genome research are published and made accessible. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1553734X
Volume :
15
Issue :
2
Database :
Complementary Index
Journal :
PLoS Computational Biology
Publication Type :
Academic Journal
Accession number :
134546112
Full Text :
https://doi.org/10.1371/journal.pcbi.1006790