Back to Search Start Over

Genome‐wide DNA methylation profiling shows molecular heterogeneity of anaplastic pleomorphic xanthoastrocytoma.

Authors :
Nakamura, Taishi
Fukuoka, Kohei
Nakano, Yoshiko
Yamasaki, Kai
Matsushita, Yuko
Yamashita, Satoshi
Ikeda, Junji
Udaka, Naoko
Tanoshima, Reo
Shiba, Norio
Tateishi, Kensuke
Yamanaka, Shoji
Yamamoto, Tetsuya
Hirato, Junko
Ichimura, Koichi
Source :
Cancer Science; Feb2019, Vol. 110 Issue 2, p828-832, 5p
Publication Year :
2019

Abstract

In the revised World Health Organization classification 2016, anaplastic pleomorphic xanthoastrocytoma (PXA) has been newly defined as a variant of the PXA entity. Furthermore, some anaplastic PXA were reported to have extremely poor prognosis which showed a type of pediatric glioblastoma (GBM) molecular profile. Recent integrated molecular classification for primary central nervous system tumors proposed some differences between histological and molecular features. Herein, in a genome‐wide molecular analysis, we show an extreme aggressive anaplastic PXA that resulted in a pediatric GBM molecular profile. A full implementation of the molecular approach is the key to predict prognosis and decide the treatment strategy for anaplastic PXA. This report suggests that anaplastic PXA consists of clinically and biologically distinct multiple entities, and genome‐wide molecular profiling may help to identify them. This new approach will be useful for predicting prognosis and choosing treatment for anaplastic PXA patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13479032
Volume :
110
Issue :
2
Database :
Complementary Index
Journal :
Cancer Science
Publication Type :
Academic Journal
Accession number :
134466023
Full Text :
https://doi.org/10.1111/cas.13903